Sjoerd B. Vos1,
2, Murat Aksoy2, Julian R. Maclaren2, Zhaoying
Han2, Samantha J. Holdsworth2, Alexander Brost2,
Christoph Seeger2, 3, Alexander Leemans1,
Roland Bammer2
1Image
Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Center
for Quantitative Neuroimaging, Department of Radiology, Stanford University,
Stanford, CA, United States; 3Pattern Recognition Lab, Department
of Computer Science, Friedrich-Alexander-University Erlangen-Nuremberg,
Erlangen, Germany
Recent 3D DWI pulse sequences can achieve resolutions up to 1mm isotropic, at the expense of longer acquisition times per volume. To acquire HARDI data with these high resolutions, the large number of diffusion directions required for HARDI can be spread out over different imaging sessions. We present a validated approach to acquire high-angular and high-spatial resolution diffusion imaging over different sessions, suggesting a head holder that fits tightly around the subjects head and in the coil. Accurate subject repositioning is ensured in each session, resulting in seamless fusion of data from different sessions.