Su-Chun Huang1,
2, Gregory J. Pauley1, Todd L. Richards1, Neva M.
Corrigan, Dennis W. Shaw, Alan A. Artru3, Annette Estes4,
Stephen R. Dager, Natalia M. Kleinhans, 1
1Integrated
Brain Imaging Center, Department of Radiology, University of Washington,
Seattle, WA, United States; 2Institute of Biomedical Engineering,
National Taiwan University, Taipei, Taiwan; 3Department of
Anesthesiology, University of Washington, Seattle, WA, United States; 4Speech
and Hearing Sciences, University of Washington, Seattle, WA, United States
Here we introduce a new analysis pipeline named tractography-based voxel-wise analysis (TBVA), which combines the advantages of TBSS and probabilistic tractography. This approach shows individual tract bundles in MNI standard space and performs voxel-wise comparisons within the tract bundle. We employed TBVA on the cingulum bundle (CB) in a group of participants with autism spectrum disorders (ASD) and age and IQ matched controls, and compared the results from conventional TBSS to the TSVA tractography results.