Abstract #3147

Distinguishing Small Pore Sizes Using Oscillating Gradient Spin Echo Sequences

Sheryl L. Herrera¹, Trevor J. Vincent², Jonathan D. Thiessen¹,³, Richard Buist³, Melanie Martin²,⁴

¹Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada; ²Physics, University of Winnipeg, Winnipeg, Manitoba, Canada; ³Radiology, University of Manitoba, Winnipeg, Manitoba, Canada; ⁴Radiology, Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada

Oscillating gradient spin echo (OGSE) sequences probe the shortest possible diffusion time scales so that the transition from restricted to hindered diffusion within the smallest structures can be detected. Here we simulate different geometries using OGSE sequences to determine the ability of the OGSE sequences to distinguish small pore sizes. As expected, OGSE frequencies corresponding to scales in the range between completely restricted and free diffusion best distinguish restriction sizes. Combining these measurements with other techniques such as AxCaliber and ActiveAx can allow for the inference of restriction sizes in the samples.