Abstract #3129

Multimodality Investigation of Microstructures by the Combination of Diffusion NMR and Diffuse Optical Spectroscopy

Alessandro Proverbio¹, Bernard M. Siow², Daniel Alexander³, Adam Gibson¹

¹Department of Medical Physics and Bioengineering, University College London, London, United Kingdom; ²Centre for Advanced Biological Imaging, University College London, London, United Kingdom; ³Centre for Medical Image Computing and Department of Computer Science, University College London, London, United Kingdom

Non-invasive histology is a key research area. Diffusion NMR (dNMR) and Diffuse Optical Spectroscopy (DOS) can provide complementary information about the microstructure of a tissue using different contrast mechanisms. Here, we developed a biophysical model of the microstructure directly informed by dNMR and DOS signals, and we applied it to a sample to estimate three microstructural parameteres. This is a proof of concept that a low level combination of information obtained from dNMR and DOS can improve the accuracy of parameters estimatation. The model was developed in order to allow an extention to real tissues microstructure.