Wendy W. Ni1,
2, Thomas Christen1, Zungho Zun1, Greg Zaharchuk1
1Department
of Radiology, Stanford University, Stanford, CA, United States; 2Department
of Electrical Engineering, Stanford University, Stanford, CA, United States
In this study, we compare the measurement of reversible contribution R2'=1/T2' of the transverse relaxation rate using nine methods characterized by three approaches: asymmetric spin echo (ASE), Gradient-Echo Sampling of FID and Echo (GESFIDE), and combined (COMBO). We found that the mean value, spatial SNR and inter-subject variation of resulting R2' maps differed significantly between methods, highlighting the importance of making a careful choice in R2' measurement method for quantitative BOLD (qBOLD) oxygenation measurements.