Andreas Wetscherek1,
2, Frederik B. Laun1, 3, Claudia Prieto2,
4, Cristin Tejos, 25
1Medical
Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg,
Germany; 2Biomedical Imaging Center, Pontificia Universidad
Catolica de Chile, Santiago, Chile; 3Quantitative Imaging-Based
Disease Characterization, German Cancer Research Center (DKFZ), Heidelberg,
Germany; 4Division of Imaging Sciences and Biomedical Engineering,
King's College London, London, United Kingdom; 5Department of Electrical
Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile
The flow-compensated (FC) intra-voxel incoherent motion (IVIM) model allows probing the characteristic timescale and velocity of the incoherent motion using FC diffusion weighted MRI. To reduce the long acquisition times required, we applied a compressed sensing reconstruction exploiting sparsity of the Karhunen-Love transform domain to a 3x undersampled data set. We were able to show that the CS reconstruction improved the accuracy of the parameter maps obtained from the undersampled data making their quality comparable to those obtained from non-undersampled data.