Abstract #3080

Diffusion Tensor Imaging of the Mouse Brain with a Cryogenic Coil at Ultrahigh-Field: Fast Imaging Allows for Cohort Studies

Hans-Peter Mueller¹, Ina Vernikouskaya², Albert Ludolph¹, Jan Kassubek¹, Volker Rasche,²³

¹Department of Neurology, Ulm University, Ulm, Baden Wuerttemberg, Germany; ²Core Facility Small Animal MRI, Ulm University, Ulm, Baden Wuerttemberg, Germany; ³Experimental Cardiovascular Imaging, Ulm University, Ulm, NA, Germany

The SNR gain of cryogenically cooled resonators (CCR)is supposed to generate high fidelity DTI data with high in-plane resolution and thin slices in order to get close to isotropic voxel resolution. That way, accurate fractional anisotropy (FA) mapping and improved isotropic 3D DTI fiber reconstruction could be obtained. The aim of this study is to keep the overall scanning time at approximately 30 minutes in order to enable the application of the scan protocol to in-vivo cohort studies aiming at DTI comparisons of murine brain at the group level.