Xin Li1, Seymur
Gahramanov2, Charles S. Springer, Jr. 1, William D.
Rooney1, Edward A. Neuwelt2
1Advanced
Imaging Research Center, Oregon Health & Science University, Portland,
OR, United States; 2Department of Neurology, Oregon Health &
Science University, Portland, OR, United States
Conventional gradient echo Dynamic-Contrast-Enhanced (DCE) MRI protocols acquire data at short but finite echo time (TE). During contrast reagent (CR) bolus passage, T2* related MRI signal reduction (mainly due to susceptibility gradient introduced by CR) may not be negligible even with short TE, especially at ultra-high field. Using a sequential multi-session DCE-MRI data collection at 11.75 T, we demonstrate that the T2* signal loss in DCE-MRI is tissue dependent and most pronounced for tissues with low CR extravasation which transiently experience large intra-voxel susceptibility gradients.