Martin M. Pike1,
Mohan L. Jayatilake1, Xiaoyan Wang2, Merryl R. Lobo1,
Xin Li1, Matthias C. Schabel1, William D. Rooney1,
Dale J. Christensen3, Jerry D. Glickson4, Rosalie C.
Sears2, Wei Huang1, Charles S. Springer, Jr. 1
1Advanced
Imaging Research Center, Oregon Health & Science University, Portland,
OR, United States; 2Molecular and Medical Genetics, Oregon Health
& Science University, Portland, OR, United States; 3Oncotide
Pharmaceuticals, Research Triangle Park, NC, United States; 4Radiology,
University of Pennsylvania, Philadelphia, PA, United States
The metabolic dimension of DCE-MRI is explored by using targeted therapy on a genetically modified mouse spontaneous breast cancer. DCE-MRI suggests a metabolic flux decrease upon therapy.