Kourosh Jafari-Khouzani1,
Kyrre E. Emblem1, 2, Jayashree Kalpathy-Cramer1,
Atle Bjrnerud2, 3, Mark Vangel1, Elizabeth
R. Gerstner4, Kathleen M. Schmainda5, Tracy T.
Batchelor4, Bruce Rosen1, Steven M. Stufflebeam1
1Athinoula
A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts
General Hospital, Harvard Medical School, Boston, MA, United States; 2The
Intervention Centre, Rikshospitalet, Oslo University Hospital, Oslo, Norway; 3Dept
of Physics, University of Oslo, Oslo, Norway; 4Massachusetts
General Hospital Cancer Center, Harvard Medical School, Boston, MA, United
States; 5Department of Biophysics, Medical College of Wisconsin,
Milwaukee, WI, United States
This study evaluates the repeatability of dynamic susceptibility contrast (DSC) based perfusion imaging using a double baseline MRI acquisition setup in 31 adult patients (18 M, 13 F, age 23-72, mean 56) with newly diagnosed glioblastoma. The images were acquired using a dual-echo, combined gradient-echo (GE) and spin-echo (SE) echo planar imaging sequence. Cerebral blood volume (CBV) and cerebral blood flow (CBF) maps were generated and evaluated within tumor regions (enhancing tumor from T1-weighted images and whole tumor including edema from FLAIR image). Repeatability was evaluated using intraclass correlation coefficients. High repeatability was obtained for mean values of perfusion maps within tumor regions.