Abstract #3023

in vivo Ultra-High Resolution Diffusion Tensor Imaging of the Medial Temporal Lobe in Patients with Epilepsy

Mansi B. Parekh¹, Robert Fisher², Kevin Graber², Ryan Purcell, Rishi Raman, Leandro Bouzon, Scott Atlas¹, Samantha J. Holdsworth¹, Stefan Skare¹, Rolland Bammer¹, Michael Zeineh¹

¹Radiology, Stanford University, Stanford, CA, United States; ²Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States

Discerning the microstructural abnormalities of the epileptogenic focus are not always possible with conventional MRI in patients with epilepsy. However, ultra-high resolution diffusion tensor imaging (DTI) may provide adequate microanatomical information to study subtle structural changes that underlie the epileptogenic focus. Recent published work from our group has shown promise in being able to study the mesial temporal lobe (MTL) structures using DTI. In this study, we further study fractional anisotropy, mean diffusivity and connectivity changes in the MTL structures of patients with unilateral mesial temporal sclerosis.