Abstract #2990

Brain Plasticity Changes in Motor Region and Dynamic Changes in White Matter After Stroke Induced by a Neural Activity-Triggered Rehabilitation Device

Jie Song¹, Leo Walton², Brittany Young², Veena A. Nair³, Svyat Vergun⁴, HuiChun Chen⁵, Dorothy Farrar-Edwards⁵, Mitch E. Tyler¹, Justin Sattin⁶, Justin C. Williams¹, Vivek Prabhakaran³

¹Biomedical Engineering, UW-Madison, Madison, WI, United States; ²Neuroscience Training Program, UW-Madison, Madison, WI, United States; ³Radiology, UW-Madison, Madison, WI, United States; ⁴Medical Physics, UW-Madison, Madison, WI, United States; ⁵Kinesiology, UW-Madison, Madison, WI, United States; ⁶Neurology, UW-Madison, UW-Madison, WI, United States

We investigate a closed-loop neurological feedback device which combines Brain computer interface-EEG and functional electrical muscle stimulation together with tongue stimulation and combines the subjects intention-to-move with the stimulated output thus providing patients with both visual and sensory feedback and direct control of the stimulus intensity. We use fMRI and DTI to elucidate the neural mechanisms by which the training with this device can facilitate brain reorganization and white matter change leading to greater functional recovery.