Abstract #2965

Metabolic and Structural Correlates of Different Patterns of White Matter Injury in Preterm Infants

Ashok Panigrahy¹,², Jessica L. Wisnowski¹,³, Rafael C. Ceschin⁴, Stefan Bluml²

¹Pediatric Radiology, Childrens Hospital of Pittsburgh, Pittsburgh, PA, United States; ²Childrens Hospital Los Angeles, Los Angeles, CA, United States; ³Brain and Creativity Institute, University of Southern California, Los Angeles, CA, United States; ⁴Children's Hospital of Pittsburgh, Pittsburgh, PA, United States

We used MRS to examine cerebral metabolism in the parietal white matter of a large cohort of high-risk preterm infants in relation to two MRI defined patterns of white matter injury and present the first evidence of altered NAA/MI ratio, T2 relaxation, and thalamic volume, in association with punctate white lesions, but not diffuse extensive high signal intensity (DESHI)