Taeko Inoue1,
Tabassum Majid2, Daniela Marcano3, Errol L. Samuel3,
Helen Zheng3, James Tour3, Robia G. Pautler, 2
1Department
of Molecular Physiology & Biophysics, Baylor College of Medicine,
Houston, TX, United States; 2Interdepartmental Program for
Translational Biology & Molecular Medicine, Baylor College of Medicine,
Houston, TX, United States; 3Department of Chemistry, Rice
University, Houston, TX, United States
Oxidative stress is the imbalance of pro-oxidant and antioxidant molecules in favor of pro-oxidants. This imbalance leads to damage of DNA, proteins, lipids, interference of key signaling pathways and has been well documented to play a key role in pathogenesis of many neurodegenerative diseases such as Alzheimers disease. As a result, there have been many antioxidant-based therapies throughout the years targeted at fighting oxidative stress. They have, however, been largely ineffective due to low radical scavenging efficacy, as well as, poor localization in needed areas. As a result, we have developed a nanoantioxidant that can potentially meet several of the currently unmet needs.