Julian R. Maclaren1,
Zhaoying Han1, Sjoerd B. Vos1, 2, Christoph
Seeger1, 3, Alexander Brost1, Nancy J.
Fischbein1, Roland Bammer1
1Center
for Quantitative Neuroimaging, Dept. of Radiology, Stanford University,
Stanford, CA, United States; 2Image Sciences Institute, University
Medical Center Utrecht, Utrecht, Netherlands; 3Pattern Recognition
Lab, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
The monitoring of neurodegenerative disease progression may be assisted by quantitative measurement of the volume of structures in the human brain. We performed 120 scans on 3 volunteers over a period of 31 days. The resulting dataset is available online and is a valuable resource for quantifying the repeatability of brain volume measurements. Results show that lateral ventricle volume, in particular, varies significantly from day to day. This could potentially mask the effects of disease and should be taken into consideration in any analysis performed using ventricle volume.