Ying Wu1,
2, Ryan Hutten1, Yi Gao3, Hongyan Du3,
Nadia Abbasi1, Robert R. Edelman1, 4, Ann B.
Ragin4
1Department
of Radiology, NorthShore University HealthSystem, Evanston, IL, United
States; 2Department of Radiology, The University of Chicago
Pritzker School of Medicine, Chicago, IL, United States; 3Center for
Clinical and Research Informatics (CCRI), NorthShore University HealthSystem,
Evanston, IL, United States; 4Department of Radiology,
Northwestern University Feinberg School of Medicine, Chicago, IL, United
States
We demonstrate the potential of an autoregional DTI and MTR framework as a sensitive strategy of brain assessment for preclinical populations. Compared to previous methods, this investigation addressed sensitivity and consistency through improved automation and comprehensive three dimensional standardized measurements of DTI and MTR. We found callosal abnormalities for both DTI and MTR in a cohort of asymptomatic HIV infection of less than one year. This autoregional framework holds promise as a sensitive tool for detecting early brain changes and monitoring disease progression.