Abstract #2860

Whole-Brain MR Spectroscopic Imaging in Adults Perinatally-Infected with HIV

Varan Govind¹, Anai Cuadra², Elizabeth Willen², Catherine Longa², Kristopher Arheart³, M. Judy D. Post¹, Monica Molina², Carmen Velazquez², Andrew A. Maudsley¹, Sulaiman Sheriff¹

¹Radiology, University of Miami, Miami, FL, United States; ²Pediatrics, University of Miami, Miami, FL, United States; ³Epidemiology , University of Miami, Miami, FL, United States

The long term impact of HIV in the CNS and its antiretroviral treatment on proton MR-observed brain metabolites of adults perinatally-infected with HIV are not characterized completely. In this study, a unique whole-brain MRSI method is used to quantitate changes in brain metabolites, N-acetyl aspartate (NAA), total-creatine (Cre) and total-choline (Cho), in a group of adults perinatally-infected with HIV by comparing it to similar data from a matched community control group.