Katherine A. Koenig1,
Stephen M. Rao2, Mark J. Lowe1, Jian Lin1,
Deborah L. Harrington3, Dawei Liu4, Ken E. Sakaie1,
Jane S. Paulsen5
1Imaging
Sciences, Cleveland Clinic, Cleveland, OH, United States; 2Neurological
Institute, Cleveland Clinic, Cleveland, OH, United States; 3Research,
Neurology, and Radiology Services, Veterans Affairs San Diego Healthcare
System, San Diego, CA, United States; 4Department of
Biostatistics, The University of Iowa Carver College of Medicine, Iowa City,
IA, United States; 5Department of Psychiatry, The University of
Iowa Carver College of Medicine, Iowa City, IA, United States
The current study used a seed-based approach to examine resting state functional connectivity in the inhibitory control network in prodromal Huntington Disease. Our findings indicate that connectivity patterns are disrupted in the prodromal stages of HD, particularly to areas involved in task attention and motor intention.