Stephen J. Sawiak1,
2, A Jennifer Morton3, T. Adrian Carpenter1
1Wolfson
Brain Imaging Centre, University of Cambridge, Cambridge, England, United
Kingdom; 2Behavioural and Cognitive Neuroscience Institute,
University of Cambridge, Cambridge, England, United Kingdom; 3Department
of Pharmacology, University of Cambridge, Cambridge, England, United Kingdom
Support vector machines are used to detect whether high-resolution brain images are from healthy or transgenic Huntington's disease mice. We found that with leave-one-out cross validation the classifier has >98% accuracy at detecting the sick animals and we applied the same trained classifier to older healthy brains, revealing that the changes seen are not confused with healthy aging.