Chuan Huang1,
Joyita Dutta1, Yoann Petibon1, Timothy G. Reese2,
Quanzheng Li1, Ciprian Catana2, Georges El Fakhri1
1Center
for Advanced Radiological Sciences, Department of Radiology, Massachusetts
General Hospital, Boston, MA, United States; 2AA Martinos Center
for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA,
United States
Accurate lesion characterization is crucial for initial staging, follow up and assessment of response to treatment in non-small cell lung cancer. Conventional PET-CT suffers from a temporal mismatch between PET and CT, due to longer PET than CT acquisitions needed for achieving good PET SNR. This mismatch yields artifacts that affect PET diagnostic specificity as well as quantitation accuracy. Gated CT can be used to correct these motion artifacts; however, however, this is not usually done routinely due to longer exams and greater radiation dose. In this work, we present a slice-interleaved golden-angle radial FLASH sequence with short-duration slice-projection navigation for lung respiratory motion measurement and respiratory motion tracking for motion-corrected PET reconstruction using simultaneous PET-MR.