Olivier E. Mougin1,
Penelope A. Gowland2
1SPMMRC,
School of Physics and Astronomy, University of Nottingham, Nottingham,
Select, United Kingdom; 2SPMMRC, University of Nottingham,
Nottingham, Nottinghamshire, United Kingdom
CEST is increasingly used to study a wide range of endogenous and exogenous species. However different species of interest overlap in the z-spectra even at high field due to line broadening caused by exchange. Here we propose a new combination of acquisition and analysis approaches to separate fast and slow exchanging species. Simulation and experimentation of a z-spectra database for two pools exchanging at different rates is presented here, and was used successfully in fitting pool protons overlapping on the z-spectra, both numerically and empirically.