Steffen Volz1,
Ulrike Nth1, Alina Jurcoane2, Ulf Ziemann3,
Elke Hattingen2, Ralf Deichmann1
1Brain
Imaging Center, University Frankfurt, Frankfurt, Germany; 2Department
of Neuroradiology, University Frankfurt, Frankfurt, Germany; 3Department
of Neurology, University Frankfurt, Frankfurt, Germany
Correcting for the receiver profile (RP) of the RF coil is a crucial step in quantitative proton density (PD) mapping. Two new RP correction methods were compared for pathological tissue: (1) bias field correction method and (2) pseudo PD calculation method assuming a linear relationship between T1 and PD in white and grey matter. Results were consistent for multiple sclerosis and stroke patients (small lesions). However, differences between the two RP correction methods were found in tumour tissue with results from the pseudo PD method being more plausible.