Abstract #2433

Quantification of Aortic Stiffness Using MR Elastography and Its Comparison to Pulse Wave Velocity: Early Validation

Aniurdh Damughatla¹, Brian Raterman², Orlando P. Simonetti²,³, Travis Sharkey-Toppen⁴, Ning Jin⁵, Richard White², Arunark Kolipaka²,³

¹Biomedical Engineering, The Ohio State University, Columbus, OH, United States; ²Radiology, The Ohio State University, Columbus, OH, United States; ³Internal Medicine, Division of Cardiovascular Medicine , The Ohio State University, Columbus, OH, United States; ⁴Davis Heart & Lung Institute, The Ohio State University, Columbus, OH, United States; ⁵Siemens Medical Solutions, The Ohio State University, Columbus, OH, United States

In aortic aneurysm or Marfan syndrome the stiffness of the aorta varies spatially, however clinical techniques provide global measure of stiffness. Therefore, there is a need for spatial estimation of stiffness of aorta non-invasively. The purpose of the study is to compare the abdominal aortic stiffness obtained using MRI based pulse wave velocity (PWV) measurements against magnetic resonance elastography (MRE) based stiffness measurements in normal volunteers with increase in age. The MRE stiffness values and PWV values plotted against age resulted in similar correlation in the in initial pool of data demonstrating initial feasibility in the same imaging plane.