Abstract #2419

Comparison of Hepatic Fat Measurements Using Dual-Echo MDIXON Imaging and 1H MRS with Fat Phantom Validation

Paul Begovatz¹, Peter Nowotny¹, Tomas Jelenik¹, Bettina Nowotny¹, Birgit Klppelholz², Guido Giani², Juergen Bunke³, Michael Roden¹,⁴, Jong-Hee Hwang¹

¹Institute of Clinical Diabetology, German Diabetes Center, Duesseldorf, Germany; ²Institute for Biometry and Epidemiology, German Diabetes Center, Duesseldorf, Germany; ³Philips Healthcare, Hamburg, Germany; ⁴Department of Metabolic Diseases, University Clinics, Heinrich Heine University, Duesseldorf, Germany

DIXON imaging is increasingly being used for liver fat quantification with a flexible Dual-Echo (mDIXON) technique recently introduced that provides a higher SNR through very short echo times. Tests of mDIXON versus 1H-MRS were conducted in a set of fat phantoms and human subjects. mDIXON showed a good correlation (slope=1.00, r=0.99, p<.001, intercept=4.5%) in the fat phantoms, and between mDIXON and 1H-MRS in vivo hepatic fat (slope=1.07, r=0.96, p<.001, intercept=1.6%). This shows that mDIXON can be used to detect changes in liver fat due to intervention in diabetics, but more work must be done for accurate disease diagnosis.