Abstract #2330

Evaluation of the Validity of Task Switching Paradigm as a Cognitive Stress Test

Mitsunobu Kunimi¹, Sachiko Kiyama², Toshiharu Nakai²

¹National Center for Geriatrics and Gerontology, Obu, Aichi , Japan; ²National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

We attempted to evaluate the validity of divalent Task Switching Paradigm (TSP) as a cognitive stress test. Fifteen young and 15 elderly volunteers participated. The brain areas with augmented brain activation depending on the difficulty of TSP task were different between the two age groups. In particular, it was observed that the contrast of Elderly against Young of right caudate nucleus and hit rate score was significantly correlated with the activation in the right caudate nucleus in the Elderly. Evaluation of the activation in the caudate nucleus using TSP may be valid to represent the aging effects on reconfiguration function.