Valerio Zerbi1,
Maarten Van Beek1, Diane Jansen1, Christian F. Beckmann2,
3, Amanda J. Kiliaan1, Arend Heerschap4
1Anatomy,
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands,
Netherlands; 2Donders Centre for Cognitive Neuroimaging, Radboud
University Nijmegen Medical Centre, Nijmegen, The Netherlands, Netherlands; 3MIRA
Institute for Biomedical Technology and Technical Medicine, University of
Twente, Enschede, Netherlands, Netherlands; 4Radiology, Radboud
University Nijmegen Medical Centre, Nijmegen, The Netherlands, Netherlands
Cholesterol released from apoE-containing lipoprotein is used for synaptogenesis and synaptic maintenance. The apoE4 isoform is a less potent cholesterol transporter, which in turn is linked to impaired synaptic connectivity. Resting-state fMRI experiments showed marked differentiation in functional networks compared with non-apoE4 carriers. We tested in apoE4 and apoE-ko mice the hypothesis that dysfunctional apoE, and further its absence, are related to reduced brain functional connectivity.