Wavelet-Based Clustering and Dynamic Analysis of Resting State Data in the Rat

Shella Keilholz¹, Alessio Medda², Lukas Hoffmann³, Matthew E. Magnuson¹, Garth Thompson¹, Wen-Ju Pan¹

While functional connectivity has typically been calculated over the length of an entire scan, interest has been growing in dynamic analysis methods that can detect changes in connectivity on much shorter time scales. Dynamic connectivity can be examined using sliding window correlation, but the properties of the dynamics depend on the window length, making a data-driven approach more attractive. We have developed an algorithm based on wavelet decomposition that clusters voxels into groups with similar temporal and spectral properties. The resulting clusters agree well with anatomy in the rat and the wavelet decomposition features exhibit sensitivity to network dynamics.