Abstract #2221

Entropy Analysis of Peak Enhancement Ratio from DCE-MRI as a Potential Marker to Assess Brain Tumor Response to Radiotherapy

Chih-Feng Chen¹, Ho-Ling Liu²,³, Yu-Jie Huang⁴, Yuan-Hsiung Tsai¹, Hsu-Huei Weng¹

¹Department of Radiology, Chang Gung Memorial Hospital, Chiayi branch, and Chang Gung University of Science and Technology, Chiayi, Taiwan; ²Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; ³Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; ⁴Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

This study assessed heterogeneity changes in peak enhancement ratio (PER) from DCE-MRI by calculating entropy in brain tumors before and after radiotherapy. There were 11 patients in the non-responder group and 12 patients in the responder group. The post- to pre-radiotherapy ratio of entropy was defined as therapeutic entropy ratio (TER). TER was significantly higher in the non-responder (1.140.14) than that in the responder (0.860.1). The corresponding area under the receiver operating characteristic curve was 0.98. In conclusion, calculating the heterogeneity changes in tumors via entropy could help diagnose response to therapy in clinical.