Cecile RLPN Jeukens1,
Harm J. van de Haar1, Jacobus F.A. Jansen1, Paul A.M.
Hofman1, C. Eleana Zhang2, Julie Staals2,
Saartje Burgmans3, Frans RJ Verhey3, Robert J. van
Oostenbrugge2, Walter H. Backes1
1Radiology,
Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 2Neurology,
Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 3Alzheimer
Centre Maastricht, Maastricht University Medical Centre, Maastricht, Limburg,
Netherlands
Using Monte Carlo simulations, we aim to determine the optimal sampling settings for reliable permeability (Ki) and plasma volume (vp) determination: 1) a single temporal resolution, i.e a single sample frequency (&[Delta]t), versus dual temporal resolution, i.e., a high initial sample frequency (&[Delta]t1=2.5s for 1:30min) followed by a lower sample frequency (&[Delta]t2=10s3min), and 2) the scan duration. We find that using a dual temporal resolution protocol and a scan duration of 15-20 minutes allows a reliable Ki and vp determination (5%/95% CI = -/+ 10%) for Ki and vp values down to Ki=0.002 min-1 and vp = 0.01.