Abstract #2170

A Two-Stage General Kinetic Model for Improved Estimation of Brain Tumour Perfusion Using Arterial Spin Labeling

Patrick W. Hales¹, Kim P. Phipps², Ramneek Kaur¹, Tina Banks³, Christopher A. Clark¹

¹Imaging and Biophysics, University College London, London, United Kingdom; ²Neuro-oncology Department, Great Ormond Street Hospital, London, United Kingdom; ³Radiology Department, Great Ormond Street Hospital, London, United Kingdom

A two-stage model for quantification of CBF and arterial volume fraction in dynamic ASL data is presented. The two-stage model provides CBF values in healthy grey matter that are more in line with previously published data from PET studies (compared to standard single stage ASL models), due to a reduction in large vessel artefacts. Furthermore, the two-stage model is shown to provide a better fit to data collected in paediatric brain tumour patients, and provide novel contrast, in terms of arterial volume maps in and around the tumour region.