Karthik Prabhakaran1,
Ryan D. Hopson1, Mark A. Elliott1, Kosha Ruparel1,
Raquel E. Gur1, Ruben C. Gur1, John A. Detre1
1University
of Pennsylvania, Philadelphia, PA, United States
The use of frequency-selective fat saturation in EPI based perfusion imaging results in spurious measurements of cerebral blood flow (CBF) if the lipid suppression is poor and inconsistent. Frequency-selective water excitation provided superior lipid suppression and yielded higher CBF measurements when compared to frequency-selective fat-saturation in a spin-echo EPI pseudo-continuous arterial spin labeling (pCASL) application at 3T.