Eleftheria Panagiotaki1,
Simon Walker-Samuel2, Bernard M. Siow1, 2,
Peter Johnson3, Rosamund Barbara Pedley3, Mark F.
Lythgoe2, Daniel C. Alexander4
1Centre
for Medical Image Computing, University College London, London, United
Kingdom; 2Centre for Advanced Biomedical Imaging, University
College London, London, United Kingdom; 3Cancer Institute,
University College London, London, United Kingdom; 4Centre for Medical
Image Computing, Dept Computer Science, University College London, London,
United Kingdom
This work explores the diffusion weighted (DW) MR signal of cancer cell lines with a selection of multi-compartment diffusion models, adapting a method for diffusion model identification in brain tissue . Characterisation of colorectal cancer cells (CRC) can improve the response of the cells to treatment. Most previous cancer cell classification studies involve invasive histological methods that alter the state of the sample. This study uses DW-MRI to quantitatively characterise CRC cell lines in vivo based on their microstructure.