Alexandru V. Avram1,
Joelle E. Sarlls2, Raisa Z. Freidlin3, Peter J. Basser1
1Section
on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health,
Bethesda, MD, United States; 2National Institute of Neurological
Disorders and Stroke, National Institutes of Health, Bethesda, MD, United
States; 3Division of Computational Bioscience, CIT, National
Institutes of Health, Bethesda, MD, United States
Given the clinical importance of the mean apparent diffusion coefficient (ADC), we revisit strategies for measuring this important parameter in a single scan and propose an optimized solution for achieving high-resolution diffusion tensor trace -weighted imaging with whole brain coverage. Mean ADC maps measured using the proposed method are similar to those obtained using conventional diffusion tensor imaging (DTI), despite the significant scan time reduction. This technique could be uniquely suited to provide a quantitative microstructural assessment in whole-brain and whole-body diffusion MRI applications where motion is problematic.