Inherent Reduction of Residual Lipid Aliasing in SENSE-Accelerated 1H MRSI at 7T by Spatially Selective SRF Optimization

Thomas Kirchner¹, Lukas Eisenring¹, Klaas P. Pruessmann¹, Anke Henning¹, ²

As a consequence of voxel bleeding and residual spatial aliasing in SENSE-accelerated in vivo ¹H MRSI, lipid signal originating in the skull region is often found in spectroscopic imaging voxels in the brain. To a certain extent, those artifacts can be contained by target-driven overdiscretized reconstruction with direct optimization of the Spatial Response Function (SRF) compared to conventional SENSE with Hamming filtering. In this work, we demonstrate that an even better spectral quality can be achieved by exploiting spatial prior knowledge to specify spatially selective priority for SRF optimality.