Sandeep Ganji1,
Changho Choi2
1Advanced
Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United
States; 2Advanced Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, TX, United States
We report in vivo spectroscopic imaging of glutamate and glutamine at 3T using an optimized echo-time PRESS-based localization method. Using our technique we achieved separation of Glu (2.35 ppm) and Gln (2.45 ppm) signals. The Gln concentration showed significant regional variation over the brain, with higher levels in gray matter dominant regions compared to white matter dominant regions. Higher concentrations of N-Acetylaspartylglutamic acid (NAAG) were well correlated with white matter dominant regions. Scan/rescan were performed in six healthy volunteers and reproducibility results are presented.