Petronella A. van Ewijk1,
2, Sabina Paglialunga1, Anne Gemmink3, Jos M.G.M.
Slenter2, Joachim E. Wildberger2, Jan F. Glatz4,
Joris Hoeks1, Matthijs K.C. Hesselink3, Patrick
Schrauwen1, Vera B. Schrauwen-Hinderling, 12, Marianne
Eline Kooi2
1Human
Biology, Maastricht University Medical Centre, Maastricht, Limburg,
Netherlands; 2Radiology, Maastricht University Medical Centre,
Maastricht, Limburg, Netherlands; 3Human Movement Sciences,
Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 4Molecular
Genetics, Maastricht University Medical Centre, Maastricht, Limburg,
Netherlands
We investigated in mice whether maternal exposure to a high fat (HF) diet increases susceptibility for cardiac lipotoxicity in male offspring on a HF-diet. Cardiac MR-spectroscopy showed initially higher cardiac lipid content in the HF/HF group (at 15 weeks) which decreased in this group with time and tended to be lower at 27 weeks compared to LF/HF. Cardiac CINE-MR imaging showed unchanged ejection fraction. Maximal mitochondrial respiration (determined ex vivo) tended to be lower the HF/HF group at 28 weeks. Maternal HF exposure lead to an initially elevated cardiac lipid content however, on the longer term, differences did not persist.