Abstract #1952

Assessment of Hippocampal Activation and Resting State Glutamate Concentration by Using Functional MRI and 1H MR Spectroscopic Imaging

Alexander Gussew¹, Gerd Wagner², Andreas Deistung³, Reinhard Rzanny¹, Patrick Hiepe¹, Marianne Cleve¹, Karl-Jrgen Br⁴, Jrgen R. Reichenbach¹

¹Medical Physics Group, Department of Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Thuringia, Germany; ²Centre for Neuroimaging, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Thuringia, Germany; ³Medical Physics Group, Department of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Thuringia, Germany; ⁴Pain & Autonomics group, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Thuringia, Germany

The present work describes multimodal fMRI and 1H-CSI measurements of memory task induced functional alternations in hippocampal activity and relationships of these changes to the resting state concentrations of the excitatory neurotransmitter glutamate in a group of healthy volunteers. Significant positive BOLD activations were detected bilaterally in the posterior hippocampus. Task induced activation revealed positive correlation with glutamate concentration, indicating regulation of neuronal activity by the excitatory neurotransmitter turnover.