Abstract #1896

Characterization of Gd-Based Contrast Agents Encapsulated in Thermosensitive Liposomes as Potential Tool for MRI Assisted Hyperthermia

Michael Peller¹, Martin Hossann², Zulfiya Syunyaeva², Rolf D. Issels², Maximilian F. Reiser¹, Lars H. Lindner²

¹Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University,, Mnchen, Germany; ²Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians University, Mnchen, Germany

Thermosensitive liposomes (TSL) with encapsulated contrast agents (CA) have been proposed for MRI-assisted thermotherapy in tumors. For such purpose an effective temperature induced r1-relaxivity change and stability in the presence of serum components is needed. Here, temperature induced r1 change of 6 approved Gd-based CAs comprising diverse chemical structures and charges encapsulated in phosphatidyldiglycerol (DPPG2)-TSL were characterized. The shelf life of TSL was also investigated.