Development of a Novel Target Moiety of SPIO Contrast Agent for Effectively Targeting to Pancreatic Cancer Cells in Vitro and in vivo

YunMing Wang¹, ShouCheng Wu¹, YuJen Chen¹

We developed an MR/optical imaging contrast agents for the diagnosis and treatment of pancreatic cancer. A highly sensitive and specific T2 weighted MR-optical imaging agent has been synthesized. The results of the experiments show significant negative contrast enhancement in mucin4 positive cell lines. As a result, we demonstrated that the T2 weighted MR-optical imaging agent can specifically target mucin4 and can be potentially used for the detection of pancreatic cancer.