Dorit Granot1,
Erik M. Shapiro2
1Department
of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel; 2Department
of Radiology, Michigan State University, East Lansing, MI, United States
Endogenous labeling of stem/ progenitor cells via intracerebroventricular injection of MPIOs has become standard methodology for MRI imaging of adult neurogenesis. While this method is well characterized in the nave rodent brain, it has not been fully investigated in disease models. Here we describe challenges in this methodology that can confound data analysis when this technique is applied to a rat model of stroke.