Martijn Hoogenboom1,
Martijn den Brok2, Erik Dumont3, Gosse Adema2,
Arend Heerschap1, Jurgen J. Futterer1, 4
1Department
of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen,
Gelderland, Netherlands; 2Department of Tumor Immunology, Radboud
University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Image
Guided Therapy, Pessac, France; 4MIRA Institute for Biomedical
Technology and Technical Medicine, University of Twente, Enschede,
Overijssel, Netherlands
High intensity focused ultrasound (HIFU) is the only known non-invasive ablation technique available to deliver high energies in a millimeter-sized focus spot. The local effects of HIFU in tissue can be separated into thermal and mechanical effects and depends on different HIFU strategies. These different effects results in various ways of tumor destruction and can be created by different HIFU settings. Therefore, this study has been set up to examine the feasibility of MR guided HIFU in a 7T animal MR system, to investigate different settings and to evaluate the corresponding tumor outcomes.