Abstract #1801

Registration of Pre and Post Intensity Modulated Radiation Therapy Prostate MRI for Quantification of MR Imaging Marker Changes and Precise Local Prostate Deformations

Robert Toth¹,², John Kurhanewicz³, Anant Madabhushi²

¹Biomedical Engineering, Rutgers University, Piscataway, NJ, United States; ²Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; ³Radiology, UCSF, San Francisco, CA, United States

In this work we utilize a finite element model with forces on the surface of the prostate to register pre-, post- IMRT MR images for determining pixel-by-pixel changes to the MRI markers, and to quantify the specific local deformations which have occurred as a result of radiation treatment. Results on 7 IMRT MR images demonstrate a RMS error of 2.73 mm with manually selected fiducials and a center of mass distance of 1.84 mm.