Asha Singanamalli1,
Rachel Sparks1, Mirabela Rusu1, Natalie Shih2,
Amy Ziober2, John Tomaszewski3, Mark Rosen4,
Michael Feldman2, Anant Madabhushi1
1Department
of Biomedical Engineering, Case Western Reserve University, Cleveland, OH,
United States; 2Department of Pathology, University of
Pennsylvania, Philadelphia, PA, United States; 3Department of
Pathology & Anatomical Sciences, University of Buffalo, University of
Buffalo, Buffalo, United States; 4Department of Radiology,
University of Pennsylvania, Philadelphia, PA, United States
Prostate cancer is the second leading cause of cancer mortality in men. Measures such as gleason scores and microvascular density (MVD) are well established indicators of CaP outcome. However, invasive procedures are necessary to obtain these measures. In this study, we seek to identify DCE MRI perfusion parameters that correlate with MVD using sophisticated image analysis and registration methods in order to establish non-invasive methods of assessing tumor outcome.