Metabolomic Fields of Human Prostate Cancer

Emily Decelle¹, Johannes Kurth¹, ², W. Scott McDougal¹, Chin-Lee Wu¹, Leo L. Cheng¹

Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Our study of human PCa metabolomics using intact tissue high resolution magic angle spinning MRS showed the potential to improve sensitivity in PCa detection and characterization, including identifying cancer recurrence status. In these studies, we discovered that PCa metabolomic information could delocalize from cancer glands to surrounding histologically benign structures to generate PCa metabolomic fields. The current study is designed to evaluate the ability of metabolomics to reveal PCa clinical and pathological status through the presence of metabolomic fields.