Application of MOBILE (Mapping of Oxygen by Imaging Lipids Relaxation Enhancement) to Monitor Changes in Tumor Oxygenation Following Administration of the Anti-Vascular Agent CA4.

Florence Colliez¹, Julie Magat¹, Marie-Aline Neveu¹, Bernard Gallez¹, Bndicte F. Jordan¹

A beneficial association between radiotherapy and CA4 has been suggested. Non-invasive mapping of tumor oxygenation before and after treatment with CA4 for the optimization of treatment combination and scheduling seems therefore particularly relevant. We recently exploited a highly sensitive endogenous contrast to map variations in tumor oxygenation, a technique that we called MOBILE (Mapping of Oxygen By Imaging Lipids relaxation Enhancement), based on the changes in the relaxation properties of the tissue lipids. The purpose of the current work was to test the ability of the MOBILE technique to monitor adequately a decrease in tumor oxygenation following administration of the anti-vascular agent CA4 in MDA-MB-231 mammary tumors, in comparison with EPR oximetry.