Jeon-Hor Chen1,
2, Ling-Chuan Chang3, Yi-Ting Wu3, Christopher
Scott4, V. Shane Pankratz4, Kathleen Brandt5,
Chin-Yu Chang3, Peter T. Fwu1, Xiao-Yong Wang1,
Min-Ying Su1, Celine M. Vachon4
1Center
for Functional Onco-Imaging,Department of Radiological Sciences, University of
California Irvine, Irvine, CA, United States; 2Department of
Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan; 3Department
of Radiology, China Medical University Hospital, Taichung, Taiwan; 4Department
of Health Sciences Research, Mayo Clinic, Rochester, MN, United States; 5Department
of Radiology, Mayo Clinic, Rochester, MN, United States
The goals of this study were to examine whether breast density and morphological pattern characterized by MRI can differentiate patients with and without cancer, and further to compare their associations with cancer risk based on MRI-density, mammographic density, or combined variables. Early results from this small cohort suggest mammographic density measures are not strongly associated with breast cancer in this symptomatic population. MRI density remains a strong risk factor for breast cancer, which is consistent with results from a prior screening study.