Assessment of Chemotherapy in a Mouse Model of Non-Hodgkin's Lymphoma Using Dynamic Contrast-Enhanced (DCE) and Diffusion Weighted (DW) MRI

Ramesh Paudyal¹, Kavindra Nath Pathak¹, Seungcheol Lee¹, Kejia Cai¹, Stephen B. Pickup¹, David Nelson¹, Harish Poptani¹, Jerry D. Glickson¹

In this study, we investigated the potential of combining dynamic contrast enhanced MRI and diffusion weighted imaging method for evaluating the response of RCHOP in non- Hodgkin lymphoma. Our results suggest that the change in kinetic model parameters and ADC values after the administration of RCHOP can be used a as an indicator of durable response to RCHOP therapy.