Chi-Long Juang1,
Chuan-Yi Lin1, 2, Sheng-Ching Liu3, Chi-Yu Yang4, Hsiao-Chuan Wen1
1Department
of Radiological Technology, Yuanpei University, Hsin Chu, Taiwan; 2Department
of Medical Imaging, Buddhist Tzu Chi General Hospital, New Taipei, Taiwan; 3Department
of Radiology, Hsinchu Mackay Memorial Hospital, Hsin Chu, Taiwan; 4Division
of Animal Medicine, Animal Technology Institute Taiwan, Miaoli, Taiwan
Tagitinin C, a major sesquiterpenoid, was isolated from the leaves of Tithonia diversifolia and was identified of its anti-hepatoma ability in our previous data. In this study the anti-metastasis ability of tagitinin C in xenograft models of Hep-G2 carcinoma was investigated by chemical shift imaging (CSI). Our results showed that tumor cells spread throughout all parts of the abdomen and metastasized to many organs of the mice after 5-25 days inoculation. We also found that tagitinin C can not only reduce the choline/creatine level but also keep most of the choline appeared near by the inoculated point.