Mor Mishkovsky1,
2, Cristina Cudalbu3, Arnaud Comment4, Denis
Marino5, Ivan Radovanovic5, Virginie Clment-Schatlo6,
Rolf Gruetter7, 8
1Laboratory
for Functional and Metabolic Imaging , Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland; 2Department of Radiology,
Universit de Lausanne , Lausanne, Switzerland; 3Laboratory for
Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne,
Lausanne, Switzerland; 4Institute of Physics of Biological
Systems, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 5Department
of Clinical Neurosciences, Universit de Genve, Genve, Switzerland; 6Department
of Clinical Neurosciences, University Hospital of Geneva, Genve,
Switzerland; 7Laboratory for Functional and Metabolic Imaging ,
cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 8Department
of Radiology, Universit de Lausanne et Genve, Lausanne and Geneva,
Switzerland, Switzerland
Cultured human glioma initiating cells (GIC) were stereotactically injected into the striatum of immunodeficient nude rats. The developed tumors were characterized by T2-weighted and contrast enhanced T1-weighted imaging. Cerebral metabolism in the tumors was studied using high-field 1H magnetic resonance spectroscopy leading to the identification and quantification of 15 metabolites representative of tumor growth and metabolism.