Abstract #1701

Investigating Tumour Cycling Hypoxia with Resting State MRI: Relationship with Systemic Changes and Influence of Noise

M. R. Gonalves¹, Simon Walker-Samuel¹, Sean Peter Johnson², Rosamund Barbara Pedley², Mark F. Lythgoe¹

¹UCL Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, London, United Kingdom; ²UCL Cancer Institute, London, United Kingdom

Solid tumours often present regions of transient hypoxia with subsequent reoxygenation. This has been found to be associated to resistance to treatment and a more aggressive phenotype. We present an approach to characterise the influence that systemic changes in blood oxygenation have in the tumour microenvironment and separate those that are specific to the tumour. We compare the approach in two colorectal tumour xenograft models.